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ea0029p1586 | Thyroid (non-cancer) | ICEECE2012

Endocrine bioengineering: reconstruction of a bioartificial thyroid lobe using its natural, three-dimensional (3D) stromal / vascular matrix as a scaffold

Strusi V. , Zini N. , Dallatana D. , Mastrogiacomo S. , Parrilli A. , Giardino R. , Lippi G. , Spaletta G. , Bassoli E. , Gatto A. , Iafisco M. , Sandri M. , Tampieri A. , Toni R.

To test the feasibility of reconstructing ex situ an entire bioartificial thyroid gland suitable for transplantation we have bioengineered a rat thyroid lobe using its decellularized stromal / vascular matrix, eventually 3D recellularized with thyroid stem / precursor cells. Sprague-Dawley male rats (220240 g) were used as thyroid donors, and lobe matrixes obtained by freezing / detergent / enzyme processing. Test matrixes were made electrondense and analyzed by m...

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Endocrine Abstracts

Endocrine bioengineering: reconstruction of a bioartificial thyroid lobe using its natural, three-dimensional (3D) stromal / vascular matrix as a scaffold

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